Research Studies

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Behavioral Activation for Substance Use
Substance use disorder is associated with a reduction in sensitivity to non-substance reward. The Life Enhancement Treatment for Substance Use (LETS ACT) is a behavioral activation treatment that aims to increase enjoyment and engagement in rewarding non-substance using activities. Our past study (Daughters et al., 2018) demonstrated that LETS ACT increases the likelihood of maintaining abstinence up to 1-year post treatment compared to a control condition.
PI: Stacey Daughters; NIH R012DA026424 (2015-2020)

Couples-Based Behavioral Activation for Dual-SUD Couples
This study will develop a manual adapting behavioral activation treatment for substance use (LETS ACT) within a Cognitive Behavioral Couples Therapy (CBCT) framework. The aim of this study will be to assess the feasibility, acceptability, and preliminary efficacy of this treatment among couples where both partners have Substance Use Disorder and are looking to reduce their substance use as a couple. PI: Louisa Kane; Faculty Sponsors: Stacey Daughters; Don Baucom (2023-2025)

Ultra-Brief Behavioral Activation for Reducing Alcohol Use (UBA)
The aim of this study is to assess the feasibility, acceptability, and preliminary efficacy of an ultra-brief (90-minute session) form of LETS ACT for reducing alcohol use (UBA) among adults with mild to moderate Alcohol Use Disorder. This is an early pilot study that will compare the interventional group to an “assessment only” control. PIs: Flavio Frolich; Stacey Daughters; NCT05086172 (2022-2023)

Harm Reduction for Injection Drug Use
The aim of this study is to assess the feasibility, acceptability, and preliminary efficacy of behavioral activation as a low-threshold substance use intervention for people who inject drugs. PI: Catherine Paquette; 1F31DA049457 (2019-2022)

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Transcranial alternating current stimulation (tACS)
tACS is a form of noninvasive brain stimulation (NIBS) that modulates the neural oscillations that contribute to mechanisms of substance use disorder. We have tested the feasibility of administering tACS in community based substance use treatment settings, and are continuing this line of research to test the effect of tACS on SUD phenotypes, with the long term goal of testing the effect of tACS combined with behavioral treatment on recovery from substance use disorder. PI: Stacey Daughters; Co-PIs: Flavio Frohlich; Ongoing

Delayed Effort for Reward Among Adults Who Smoke Cigarettes
This study is investigating the association between neural oscillations, delayed effort for reward, and smoking behavior in adults who smoke cigarettes.
PI: Stacey Daughters; Co-PI: Christian Hendershot; PulvinarNeuro, NIH R43DA054848-01; Ongoing

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